I agree that it depends on whether you want humans to interact/interpret the software at all, but I'd push back on "mostly human preferences." Do you think that how something feels is mostly a matter of human preference? Intuition and aesthetic sensibility are distinct from preference, and both play a role in research mathematics and scientific discovery as well as in art. There is also (human) cognitive affordance which I think is important for human code review. That said, I'm sure there is a language and coding style that optimises for both human and machine processing that is much better than what we have today.