A Jewish comedian made a joke about how jews (only in the US*) were offended that Ferengi in Star Trek were based on them - "why would we assume these ugly greedy people are _us_?"
*Outside the US, it looks like the Ferengi are mocking American capitalist culture.
Wish you’d been more specific, “a Jewish comedian” sounds like the setup for a joke.
Is it true that the Ferengi were based on Jews? I suspected so, but then I also considered they may have been influenced by the Chinese.
I think that is a bad example. I haven't heard of Jewish people being offended by Ferengi, but anti-Semitic depictions are very often exactly "ugly, greedy people" (just look at any Nazi propaganda). Once it becomes a common thread it works less as a defense.
I imagine "small hands" would similarly work poorly as a defense against a defamation suit from Trump: he doesn't have to claim he has small hands, only that he is often depicted as having them.
When being defensive about the genocide, some people invoke against the protesters, e.g. "Where were you when the atrocities in Sudan were happening?", admitting that the genocide being committed is as bad as the Sudan conflict...