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jollyllamatoday at 5:24 PM3 repliesview on HN

They wouldn't be selling the placebos if the real stuff were accessible. That's the real answer. The article mentions this but just accepts the inaccessiblity of the real thing as a given.

You used to be able to get Nyquil with real sudafed in it. That was the gold standard. It's not even available behind the counter anymore, presumably because they can make more money from morons buying the placebos.

As an aside:

> In January 2011, the FDA set a maximum amount of acetaminophen that could be packaged in combination opioids like Vicodin or Percocet. The odds of hospitalization due to opioid-related acetaminophen toxicity plummeted.

Yeah, the acetaminophen was there to PREVENT abuse of the Vics and Percs 'cause you'd overdose on the acetaminophen first. Sure, there was an easy workaround, but that was it's intent.


Replies

MichaelDickenstoday at 6:30 PM

> It's not even available behind the counter anymore, presumably because they can make more money from morons buying the placebos.

What do you mean "morons"? Say I'm a normal person who doesn't habitually read magazine articles about drug effectiveness. How am I supposed to know that phenylephrine doesn't work? It's in the drug store and they're selling it as a decongestant; I have good reason to believe it will decongest my nose.

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stronglikedantoday at 5:33 PM

> you'd overdose on the acetaminophen first

which is a much, much worse way to go, apparently

lokartoday at 6:05 PM

I’m not sure. Another explanation is that it is accessible, with a small amount of friction.

But then drug makers realize they can get more sales by selling a placebo that won’t have the friction.