The intrusiveness of these systems varies significantly between manufacturers. Don't buy one with an annoying, intrusive system.
There is a minimum intrusiveness required by law, though. One could even say it's intrusive by design, depending on your perspective
Most of the rentals around my neck of the woods are VWs or entry-level Mercedes. The two seem approximately equally bad; they both have the exact same problems with cruise control, lane assist beeps, speed limit beeps, "take a break!" beeps, and so on.
I've heard that Dacia has some models that are like 2008 throwbacks, with "modern" annoyances kept to a bare minimum, but they're considered too low-market for the rental companies, I suppose. I'd consider that sort of thing if I were looking to buy a new car, money no object.
But really a well-maintained vehicle that's ~15-20 years old suits me just fine.