Very different threat model though. Commercial aircraft aren't sensitive to keep-your-eyes-on-the-road failures with seconds-scale latencies, airlines require autopilot use, there is a copilot present at all times, the FAA very strictly regulates work hours and substance use, etc...
Sure, don't nag a pilot who is already very well backstopped by the existing solutions. Your uncle coming back from the bar at 2am doesn't have any of that.
Repeated nuisance alarms have the same effect on all humans, not just on pilots - it trains them to ignore the alarms. Eventually this will lead to non-nuisance alarms being ignored and lives being lost.