Einstein's discoveries were based (to a large degree) on negating very specific parts of scientific orthodoxy and then taking the steps forward to carefully derive results with those rejections in place.

LLMs are aggressively trained to reproduce facts and consequently struggle to reject orthodoxy. There isn't any reason they can't, in principal, make big new discoveries just by getting lucky, which is sort of also how humans do it, but its ok to acknowledge that current AIs aren't so good at certain things.