Another +1 to cloud sandboxes (and exe.dev) vs laptop sandbox.
Runs 24/7 completely air gapped from your laptop.
You also want a service proxy so the sandbox can access GitHub or Stripe without keys accessible to the agent. I haven't seen many of the laptop sandbox tools do this, where exe.dev does it out of the box with their "integrations".
I usually drop my own binary agent coding toolkit inside the sandbox so I have things like a code browsing and review right there in every sandbox too.
https://github.com/housecat-inc/scratch
Like you I also have a Mac Mini I've thought about making into my own 24/7 dev box, but building this vs buying 50 VMs from exe.dev for $20/mo doesn't add up for me.