There are few ideas which come to my mind, some might be far fetched, taking NPM as an example.

- Restricting packages with similar names as of popular packages restrict expres because express is a popular package.

- Imposing stricter 2FA checks on accounts of authors of these packages.

- Making sure that published packages don't have vulnerabilities and clear npm audit.

- Alerts in case these packages contain a dependency which is new / relatively new.