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Sleep regularity is a stronger predictor of mortality risk than sleep duration (2023)

414 pointsby bilsbietoday at 11:46 AM189 commentsview on HN

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petilontoday at 1:45 PM

Magnesium supplementation solved my sleep issues.

I have seen many doctors, including sleep specialists, regarding insomnia. They all pointed to one source as the reason for the sleep issues: stress. And they all wanted to put me on prescription sleeping pills. I said no to that. Sleeping pills can cause dependence, and they often treat the symptom rather than the underlying cause. As a software developer, I am used to finding and fixing the underlying problem instead of relying on the quick fixes these doctors were offering me.

After much research, I figured out what I believe was the underlying problem, and the fix for it. The underlying problem was magnesium deficiency. As a software developer, I spend much of the day doing mentally demanding work. This is the kind of stress the doctors were talking about. Stress can increase the body's demand for magnesium and may contribute to low magnesium levels.

The cells in our body depend on minerals such as calcium and magnesium for normal function. In muscle and nerve cells, calcium helps switch the cell into an active state, while magnesium helps keep that activation under control and supports the return to a resting state. When you are low on magnesium, your muscles may remain tense and your nervous system may have a harder time settling down. That can contribute to muscle stiffness and difficulty sleeping.

The solution, in my case, was magnesium supplements. They fixed my muscle stiffness issues and my sleep issues. A special form of magnesium called magnesium L-threonate may be especially helpful for the brain because it appears to raise brain magnesium levels more effectively than some other forms.

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A1kmmtoday at 12:32 PM

I wonder how much of this is driven by confounding variables they haven't accounted for.

They do factor in shift work as a categorical variable, and employment status as a categorical variable not taking into account occupation. But probably occupation (not a variable here) interacts with sleep status. Any job that involves a lot of flying (pilot, crew, people travelling for business) get more cosmic radiation exposure, for example, and potentially more sleep disruption. Certain operations and manufacturing jobs correlated with exposure to carcinogens also likely correlate with less regular sleep, possibly in a way that isn't corrected for by the limited shift work categories.

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djoldmantoday at 12:29 PM

As always with a lot of these: it's not saying causation.

You might measure the speed of your car by putting your hand out of the window and notice that the wind force on your hand is strong when the car goes fast.

Putting your hand out of the window and then blocking the wind with a book doesn't make the car slow down.

Keyword: "associated"

EDIT: I meant to communicate that it doesn't make the car slow down as much as your hand behind and blocked by the book (feeling almost no wind), would imply.

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ssgodderidgetoday at 12:25 PM

Couldn’t this effect be classic cause vs correlation?

Perhaps someone who has a consistent schedule is hypothetically more likely to make healthier choices on average?

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irenaeustoday at 3:31 PM

I read the abstract, pretty interesting. I did a word search for "wake" looking for if they talked at all about early waking times being correlated with overall regularity, as that has been my personal experience. Unfortunately they didn't talk about it, or if they did I couldn't find it.

AbstractH24today at 3:16 PM

I have epilpsy, with an implanted device that both acts like a pacemaker and records my brainwaves.

Basically my doctor's biggest concern right now is making sure I don't die in my sleep because of something the device records that I and my wife never even know happened. Its a point of debate right now how much to disrupt my life with side-effects to do that.

small_modeltoday at 2:41 PM

I do bi/tri phase sleep, 6 hours at night, and 1-2 naps a day (I work remotely so allows me to nap when I want) This is the best, sleep when you need to you body knows best.

Do you think our ancestors slept exactly 8 hours a night from 10pm to 6am? No they slept when they wanted.

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sajithdilshantoday at 1:50 PM

My problem is that I'm always sleepy throughout the day and when I have to go to bed at nigh, then I feel so active and energetic, as if my body tries its best to avoid sleeping.

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bkazeztoday at 1:42 PM

Having just spent a few months reading circadian entrainment papers for a circadian rhythm app I just finished,[1] I wonder if this effect might be about circadian amplitude[2] (rather than phase, which has gotten more attention).

[1] https://www.impulsearc.com/wavelength/

[2] e.g. https://www.nature.com/articles/s41540-023-00300-w

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plutomeetsyoutoday at 2:46 PM

> Adjusted R2 values for each model were 0.085 (linear), 0.118 (quadratic), and 0.125 (cubic)

I get the study design is not causal and all, but this R^2 looks very underfit for a study that claims a stronger predictor?

markus_zhangtoday at 12:45 PM

I kinda realize that the most important factor for personal success (whatever kind of success you want) is mental stability.

Like, John Carmack said that he NEVER burned out, never went into a dark corner (verbatim from his interview), and everyone agrees that he works like a machine. And I don't think he actually spent a lot of mental training to achieve that stability, because, he has been like that from a young age. This is THE best thing you can have in the world, if you want to achieve something, anything. If you don't have the mental toughness, you won't be able to make through that 10,000 hours (cliche, I know). I guess that's also why many self-help book talk about being consistent -- to be consistent, is to have mental stability. And I think there is a whole difference, between someone who trains his mental to stay stable for 6 months, then collapse, from someone who actually doesn't need to train and just be stable somehow.

This also leads me to realize that good sleep is one of the fundamentals of a stable mind. As a parent, I actually don't remember when was the last time I had a good sleep, and my definition of a night of good sleep is perhaps just trivial for someone else. At the same time, I consider myself lucky, because at least I don't suffer from serious mental issues. I still have a job and a house, and that's better than many out there.

This then leads me to despise the human body. It is a machine so delicate that you have to be very lucky to be super productive, whatever your definition of being productive is. It seems to ignore the input in short term (e.g. you can eat garbage food for a month and nothing really happens, or, you can sleep 4-6 hours every day for the last 6 years and still function normally), but once the long term shows up it is very hard to reverse. And there are so many theories focused on it that we have no idea which one is best for the individual. You might as well spend years doing A/B test on yourself and still have no idea what the hell is going on. Or you need to be super rich to have some medical team monitor you 7/24 to figure out what the hell is going on.

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shykestoday at 12:15 PM

Well, I'm screwed...

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mhitzatoday at 2:00 PM

I'm really pissed that I went through 6 cloudflare captcha loops with no result. I swear they're guarding this website from VPN users as if it's the fort knox.

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elcritchtoday at 12:20 PM

Well that sucks, given I have a gene variant related to delayed sleep according to 23andme.

Last year I did an experiment of sorts while unemployed for a time and found that if I just slept and woke when tired that my sleep time would naturally recess and eventually "flip" after about a month.

My entire life I've wondered why I feel incredibly tired and found waking up so difficult. Turns out that if you follow your bodies dominant sleep cycle it's a synch to wake up. Unfortunately, it doesn't work with modern life very well.

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manceraydertoday at 2:06 PM

What's missing is how much ability you have to sleep, rather than some sort of sometimes controllable factor like schedule. In my case, my brain wakes me up with anxiety one hour or more before the alarm rings (I never check time, I'm guessing). My room is always cold and relatively dark - not photo development dark, but not far.

The cortisol spikes are what get me. I can drink or not drink, exercise or not exercise, take magnesium or not take magnesium. The brain wants to tell me at 630 or 7 all the things that can go wrong or todos, instead of letting me sleep til 8. Sometimes it's much earlier than that.

I also wake up at the slightest sound or movement. It's been like this since I was a child. I'm defective, and all the bro science Youtube videos with top 10 science -based 'hacks' don't solve the problem. Know what does? Anti anxiety medication, but doctors don't prescribe benzos anymore.

bdcravenstoday at 12:39 PM

As my diabetes has progressed, I find myself sleeping more odd hours (it can be hard to fight off the tiredness that comes after a meal), and I can be frequently woken up my extreme lows where my body is screaming for carbs.

ChrisArchitecttoday at 2:09 PM

(2023)

Some more discussion then: https://news.ycombinator.com/item?id=42022151

ck2today at 12:34 PM

because of how we evolved biologically, there are some processes, particularly in the brain and not just the body, that can only happen during sleep

like "garbage collection"

ie. https://pmc.ncbi.nlm.nih.gov/articles/PMC4651462/

pullruntoday at 1:32 PM

[flagged]

tyiztoday at 1:43 PM

[dead]

Jamesmygov146today at 1:16 PM

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el1s7today at 12:46 PM

Interesting, though it seems quite annoying to read research papers with all that jargon without using an LLM

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SkyPunchertoday at 1:00 PM

This makes sense to me as a correlation. Mental health disorders alone seem like they’d contribute significantly.

ADHD, for example, is correlated with both sleep cycle issues and worse outcomes in life (including higher rates of crime and participation in risky activities).