This is different. There’s the plant. Contains about 1.5% mitragynine.

Then there were purified extracts of the active alkaloids in the plant. Started around 30% mitragynine years ago now in the 85% range.

Then there were synthetic derivatives of mitragynine (7oh, mgm-15, etc.). These are much more fun/addictive and surprisingly safe. Almost all “overdoses” involved a mix of alcohol or other drugs. Much safer than fentanyl or traditional opioids because it doesn’t meaningfully trigger respiratory depression leading to asphyxiation. Unfortunately, they’re also addictive. The harm level, imho, was somewhere around alcohol or nicotine.