I have actually had a ton of success using Strassen matrix multiplication kernels with extra structure in custom CUDA kernels (e.g. a covariance matrix is symmetric positive definite, or can be represented with Cholesky, and that comes up in a ton of useful computation). It's been a couple of years, but IIRC I would find it would start to win over the standard kernels at ~n>2500 or something (and in addition to Strassen was also exploiting the explicit structural constraints of the matrix, so not a completely fair comparison).