I'm running my own home server on an old 2014 Mac mini, 24/7 basically. It both has a SSD and a HDD (old "Fusion" disk type of machine, but I use both parts separately, the SSD part for the OS, the HDD part for the data.)
A few days ago the HDD had its 100,000 Power_On_Hours anniversary. :) According to SMART this is way past the expected/ designed life time of the disk (the normalised value reports "1" since a few years when the disk hit about 42,000 Power_On_Hours)
So you never know. It either works or it doesn't. You have backups for the worst case.
My main desktop machine with assorted components is from 2014, also with an SSD and HDD. Each component has lasted all this time somehow. The total uptime of each drive is 11.5 years (101,023 hours) with 159 power cycles. The SSD is 256 GB and has 71 TB written, it's my main drive. It has 46% lifetime remaining, I hope everything lasts another 10+ years.
Reminds me of the old forum posts where people show off their uptimes.
Uptime is fine, until you restart. And poof
Not unlike a combustion engine, cycles can do more damage than hours.