I use Adguard/wipr to great success. Why's uBlock Origin better? Also, wipr now has filtr, which provides URL filtering at the macOS level, so it's as efficient as it gets.

Agree. I've never seen any single ads so far.

Even the ads on the Youtube are block by default. It's quite buggy though.

1Blocker has been rock solid for me. Got it after reading about it on Daring Fireball and now I can’t use a Mac without it.