At least the blocker I use, uBlock Lite, isn't nerfed. It doesn't have Manifest v3-ish limitations, and can do dynamic blocking, injection, etc.
uBO Lite is exactly MV3, it has most of MV3 limitations plus its own limitations comparing to Chromium. Safari just auto converts MV3 codes to Safari's own blocking engines.
It cannot do dynamic filtering [1]. Another big one I forgot about is no CNAME uncloaking. Don't get me wrong, uBOL is still a great add on, it's just not possible to do everything you could with the manifest v2 version.
[1] https://github.com/uBlockOrigin/uBOL-home/wiki/Frequently-as...