Ive self-hosted my email server since 1999. It started in a closet at home in San Francisco. As things got more restrictive (residential ips being black holes) I moved to a Colo. but now I'm back to hosting it on my server in my cellar. I have a fixed ip from my provider init7 (Switzerland) that has never been blacklisted. Reverse dns is set up. All the acronyms like spf, dkim, dmarc are set up. I have no problems sending to Microsoft and Google email addresses.

So I'm doing it now but I'm ready to switch back to one of my Colo servers at any time and I won't be surprised if I have to at some point.