In a conventional aircraft you sit on the roll axis. In a blended wing body design you can have off-axis motion that can increase motion sickness. Rather than rolling with the longitudinal axis of the aircraft, you move up and down when the aircraft banks. Not necessarily a deal breaker, but an additional difference to deal with.

No way. Looking out the window is one of the joys of flying.

Picking out my house, seeing tiny cars on a remote highway, etc. Even 100+ MP cameras and high resolution screens won't come close to that level of detail.

The gates thing was my first thought when I saw the design although a staircase on the tarmac could be a cheap workaround.

IIRC, minimum one window for each rows is a safety requirement, so that firefighters can see inside a burning plane or something. I think that is believed to be how that fence appeared.

I don’t know how many people are claustrophobic, but for me this would be a non-starter.

Edit: apparently 12.5% of the population has claustrophobia. If 5% of flyers choose a different airline due to simulated windows that would wipe out any cost benefit from fuel savings.

I give absolutely less than zero f's about no windows for 2" more legroom.

What do economy seats look like? I can't imagine they all have wrap-around video...

Be nice to not have to deal with that one guy who didn’t close their window when it’s dark cabin time on long multi-Timezone flights; leaving the sun to blare in when you’re really trying to get some shut eye.

Would dropping airplane windows lower radiation exposure somewhat, especially on those polar routes?

the biggest challenge would likely be training pilots to a new cockpit and flight profile

No passenger windows is the correct way to go. The screens can actually show anything, not just replace a window.