New HIV vaccine shows unprecedented success in preclinical study

The most interesting point of the article for me is that this vaccine appears to be a series of shots which act as a curriculum for the immune system. Each one slightly different and targeting a different stage of B-cell development. I've never thought of vaccine series working like that, so it was a new and impressive idea.

While HIV vaccine research is an exciting field, it's worth pointing out that halting HIV transmission is, practically speaking, a solved problem with oral and injectable reverse transcriptase inhibitors. The ongoing loss of life and health due to HIV could be stopped if we cared enough to invest resources in wide-scale PrEP availability and public health education. Waiting for an HIV vaccine is the domain equivalent of hoping fusion power will solve our energy needs. Other solutions exist already; we just have to use them.

Phase I trials happening now. Godspeed to them. It’s where most HIV vaccines die

Tested on rhesus macaques. Worked well for 44% of them.

It's a positive step, but still a fair way off for humans.

I have to admit that given how many times we have been here, I struggle with being excited about any news about a HIV vaccine until we see results from humans. Just way too many times of hope.

That being said, I don't understand enough to parse this very buzzword heavy release. Is this fundamentally different than the every 6 month vaccine we have now and is a more traditional vaccine or is it just continuing on that trend?

Congratulations, I hope the vaccine shows the same highly positive results in humans as it did in the other primates.

Jury is out until the overall health effect is shown to be positive

This follows a widely renounced successful treatment drug too right?

I wish people doesn't let their guard down because of this

OK this sounds fantastic, but is it going to be another case of an expert dropping in on this thread and going "Ah, 100s of these come out every month. It's promising but nowhere near human trials yet."

Been there more times than I can count

Wait, really? Gonna have to look into this