We already have anti-trust and other regulation to manage this problem, we simply need to use it.
There's no end of competition, the world changes, companies bloat and make bad choices, smaller competitors can react and change faster - it's only in our corporate hegemony that we don't consider that a viable alternative.
Companies also learn from history, and with enough data, can make perfect decisions in real time. The end result, is you end up with “Final Companies”, where a market becomes so dominated an entrant cannot even start up, because it requires operating to even greater perfection just to stay in the game.
End of antitrust is the decisive victory.