Interesting project! A long term vision for MacOS applications is feasible given the success of WINE/Proton with Windows applications.
Are you familiar with the Darling project? https://github.com/darlinghq/darling There's an open PR for ARM64 support https://github.com/darlinghq/darling/pull/1753 Could you combine efforts or do your goals differ too much?
Wine got a lot of support from games, even today productivity apps are often much less supported.
In their "License" section on Github, they write "This project is not derived from Darling." - so they clearly are familiar with it.