The general challenge becomes integrating the fractional front-end code written in your backend-language that compiles to JS with the rest of the JS ecosystem.
JaneStreet have a love of writing their own stuff from scratch so it doesn't apply to them but it might to you.
Hence most people end up with frontend-as-backend rather than backend-as-frontend.
Similar attempts include Scalajs.
The general challenge becomes integrating the fractional front-end code written in your backend-language that compiles to JS with the rest of the JS ecosystem.
JaneStreet have a love of writing their own stuff from scratch so it doesn't apply to them but it might to you.
Hence most people end up with frontend-as-backend rather than backend-as-frontend.