> A lack of resistance and no sanitation
Precolombian north america actually had really sophisticated sanitation. In urban areas they pretty advanced waste management. In other areas, a lot of their seasonal mobility was possibly driven by sanitation needs. And they have really in depth practices around the ways they treat waterways and waste placement.
The problem was actually the exact opposite. Compared to Europeans, they were obsessive about soap and cleanliness. But Europeans lived in really dense villages alongside their livestock for many generations and they suffered greatly from it. The history of Europe is basically one outbreak after another. But ofc over time some amount of immunities developed
Maybe if North Americans had less sanitation and kept livestock they would've developed their own deadly diseases too that would've killed Europeans.
> Precolombian north america actually had really sophisticated sanitation.
I don't know what this means. Moving to another location is practical, but not sophisticated.
This is commonly repeated, but if you go look at actual record keeping - at the history of early North American and Caribbean/Bahamas colonization through the period where there stopped being as much cross-cultural contact - we see epidemic after epidemic wipe our colonials as much as any. The mortality rate is staggering - even places that should have shown this the most - Haiti for example, the documented evidence was far closer to 100% mortality to Europeans, and significantly less for indigenous. Coming to Haiti during the Haitian revolution was a death sentence for all of the people who lived in squalor in one of the densest cities in Europe - Paris.
Cultures coming together historically were deadly. There is a school of thought that argues that the Persian and Roman downfall was directly associated with the ability of diseases to transit roads.
Of course, this is the stuff that we have records for. It's possible that there was a undocumented mass extinction event, But I tend to be skeptical of historical claims that are based on extremely localized and limited archeological projections.