> I think the deepest explanation is in general economic and cultural factors.

I would say that this is very on point. Even during the renaissance "inventing" was a hobby for the aristocracy, as the author gets around with Giovanni Fontana. I'm not sure if a bicycle would've been a "cool" invention at the time. Because what would you do with it?

For the majority of people there was very little need for personal mobility in society. I know we have this nice fantasy idea of towns having taverns and getting visitors, but in reality, most towns didn't even get what we'd consider a modern pub until the industrial revolution. Sure there were ale houses, but an ale house wasn't a permanent establishment, it was simply whomever had most recentely brewed beer. You'd bring your own chair, and your own cup. So even if you had a bicycle you would frankly have nowhere to go.