DNS based adblockers have strictly worse adblocking capabilities than manifest v3 adblockers. I mean, sure they have their uses (eg. blocking ads/telemetry in apps or whatever), but bringing them up in this context doesn't really make sense.

Some ads (e.g. I know YT ads used to be this way, haven't looked recently) can't be blocked at the network level because they are served from the same domain/servers as the content.