Interesting. Part of the reason I was eager to use retatrutide was the reversibility. Fantastic drug and entirely reversible. I self-tested and the effects I had on it were reversed entirely in its absence. Similar to caffeine or amphetamine at the doses I have tried (which are not high), removing the intervention resulted in a return to a prior state over a fairly short period. I'd say that, in general, some of the good properties essential to an intervention for a non-debilitating condition are:

* uniform dose-response: easy to increase effect by changing dose

* reversibility: automatic reversion to pre-intervention in a short-term is gold standard - allows for regret escape

* low-cost

GLP-1 drugs have these properties which I like. I'm surprised to hear that someone would prefer the alternative, but I must imagine that cost and the dosing structure (sub-q injection is annoying) must dominate decision making here.

GLP-1s aren’t “forever drugs.” They’re eliminated so fast from your system you need to keep taking them to keep the effect. That’s the opposite of a forever drug. If you go off them, you just return to the way you were.

Do you have the same concerns about water or food? Why does it matter that it stops benefitting you if you stop taking it?

uniquely among maintenance drugs some people report saving money on GLP-1s, they spend less on food than the drugs cost... But think of the farmers!

Bariatric surgery has most of the same upsides as GLP-1s and is a one-time cost. But I agree with the other commenters that "forever drug" is mostly fretting without an actual reason. The Hunger that engineered foods are deliberately designed to induce is a forever thing too, now there's a counterweapon.