Thank you. That is insightful and well written. And corresponds with academic literature as far as I have read.

I find it extremely interesting that GLP-1 agonists and GLP-1 receptors are highly pulmonary.

(There seems to be a persistent correlation between detailed pulmonary mechanisms, biology, responses… and neuroinflammation. Which does make sense when we consider the metabolic demands of the brain, which can be highly localized and sensitive to fine variances in supporting system capacity.)

My from-the hip take – from the hip!, no judging pls; It's a hunch, working to falsify it – is that… everything that makes humans aggressive to someone. Every feature someone can present that increases the odds of aggression… is a heuristic for neuroinflammation.

It's a lot of things, but neuroinflammation is a pretty consistent good match as core heuristic.

As in: GLP-1 agonists do reduce neuroinflammation. And then the hunch: This generally and ubiquitously reduces the aggression-induced features thereof.

(This take is somewhere between riffing on concepts and a surprisingly earnest and mechanistic theoretical perspective. Started as jokey banter but it's kinda hard to unsee it. not sure where else to place it, haha.)