For sure we still need to find out many related outcomes.

Last year it become known that it increases (high relative risk, low absolute risk) non-arteritic anterior ischemic optic neuropathy (NAION), ie sudden, sometimes permanent vision loss.

https://www.ema.europa.eu/en/news/prac-concludes-eye-conditi...

If it reduces inflammation and causes weight loss, I find it impossible to believe you can just stop and not get rebound on both.

Which to me just sounds like every other addictive drug. Paradise while you’re high, and eventually you pay for it.