As I mentioned elsewhere, eg. femur can take at least 30x body weight, and we've got two to carry us. If a giant is 10x the size, and femur is just scaled linearly, even with 10x the relative weight, it can still take 3x giant's body weight. So perhaps no jumping on one leg anymore, but walking or light jogging should be fine.

But, their bones could also have larger cross-section and a giant could be stockier yet still appear "human like".