Actually a key element of modern Republican strategy is figuring out exactly how to ensure their base vote against their interests.
In some ways the distinguishing difference for the Democrats is that they haven't proved to be very good at it. "We should fund somebody else's genocide" is against your interest and turns out that selling it as "We're protecting Jews" didn't work very well in their primaries. Tens of millions of idiots voted for Donald Trump, a wealthy rapist who they knew wanted to steal from them and destroy their country, of course they're voting against their own interests.