alt Hacker NewsSildenafil [0] was synthesized to treat high blood pressure. Erectile disfunction was a side effect that raised much more interest.
Tadalafil [1] followed the path of Sildenafil about the phosphodiesterase type 5 (PDE5) enzyme inhibitor.
Help to live longer was the main objective since the beginning.
[0] https://en.wikipedia.org/wiki/Sildenafil#History [1] https://en.wikipedia.org/wiki/Tadalafil#History
I invested heavily in ICOS when they launched, they had Bill Gates money and were looking for ways to extend lifespans and solve inflammation.
And all we got was another boner pill.