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perrygeotoday at 2:27 PM1 replyview on HN

Nope. Lactate and lactic acids are by-products of fatigue, not causal agents. Far from being toxic, elite athletes are even intentionally ingesting lactate as fuel these days.


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nradovtoday at 2:32 PM

Correct. Related to that, accumulation of free hydrogen ions is associated with acute fatigue (although not necessarily related to chronic conditions like OTS). This is why some endurance athletes are now taking sodium bicarbonate supplements.