logoalt Hacker News

nradovtoday at 2:28 PM1 replyview on HN

Oxidative stress could be a factor in some cases but connecting that to dopamine metabolism seems like a real stretch.


Replies

Noaiditoday at 2:38 PM

A real stretch you say? Meaning that it’s something that they definitely would not study at all?

https://pubmed.ncbi.nlm.nih.gov/1601559/

When training is effective or the athletes are not exhausted, the decrease of the excretion rate--with the exception of dopamine--is more likely to be lower (noradrenaline, adrenaline). Generalization of these results requires further expansion of the experimental basis.

Editing to add a more recent study(2025):

https://www.sciencedirect.com/science/article/pii/S266633762...

"Oestradiol, total catecholamines and dopamine levels were higher in OTS athletes."

The more catecholamines you release the more H2O2 you will produce.

And this one(2025):

https://pmc.ncbi.nlm.nih.gov/articles/PMC12010411/pdf/main.p...

Oxidative stress, mitochondrial damage, and inflammation create an environment in which DNA damage can occur. The results of animal studies have shown that overtraining can cause DNA damage in blood, skeletal muscle, and liver.