To give you a sense of the computation needed, a spatiotemporal physics simulation of a minimal (493 gene) bacterium's full 105 minute cellular cycle took 4-6 days of GPU hours on two A100s.

https://www.sciencedirect.com/science/article/pii/S009286742...

Compare this with a c elegens nematode: ~20000 protein coding genes and 959 cells, with all the extra machinery you'll find in a eukaryotic cell.

I'm reading this as both a question of raw simulation surface and combinatorics.