It's not about being uneasy. I've had six jobs in my career that are all over the lot with respect to software engineering. How to work with specific influential personalities like the C-suite, picking up and gaining some expertise with the company's stack, establishing the proper processes and engineering discipline for mentoring and growth. Over time I see the decisions that the company has made and what has worked and what hasn't, and also the reasoning behind those decisions, and I can bring that knowledge forward when the company tries to iterate on their current processes. That is immensely valuable in maintaining continuity in the business and making good decisions that don't repeat past mistakes.

I don't know for a shortcut for this. It's simply experience, though I do find the more industries I work in and the more jobs I work, the more I can pattern match across that experience to make better decisions faster in a new job.