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btillytoday at 12:29 PM1 replyview on HN

That's the viewpoint of everyone sensible outside of Alzheimer's research.

Those in it are still throwing billions per year at the idea.

Meanwhile, back in reality, no amyloid-beta drug has had any clinical effect in humans, other than reducing the plaques. But both the shingles and RSV vaccines are proven to reduce Alzheimer's risk.


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isollitoday at 12:41 PM

Which did not stop the FDA from approving a useless anti-amyloid drug, leading to the resignation of several experts, one of whom called it "probably the worst drug approval decision in recent U.S. history" in his resignation letter. [0]

I can't think of a good reason why this happened.

[0] https://www.npr.org/2021/06/11/1005567149/3-experts-have-res...