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justonceokayyesterday at 11:28 PM3 repliesview on HN

So did you take them and have a bad time? Because they definitely work for me and I doubt a placebo could have such a large effect on the 48 hour stomach pains I used to get alongside my frequent panic attacks.

I find it funny that people complain about emotional blunting when that is the entire purpose of the drug. I would prefer not to live on the razors edge ever again. I’ve had chronic anxiety and depression ever since I was a child, though.


Replies

D-Machineyesterday at 11:32 PM

For some people the emotional blunting is desirable, especially as you said, if the problem is chronic anxiety. But for many other people, their depression is defined by a lack of positive affect and anhedonia, meaning that emotional blunting is literally making things worse.

Depression is highly heterogenous, and I am glad the medication helped you.

jakeboltoday at 12:07 AM

SSRIs have much more clinical evidence of efficacy for addressing anxiety disorders vs a placebo than depression. The effect size is ~0.7 vs 0.2 in meta studies.

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JoshTriplettyesterday at 11:38 PM

> I find it funny that people complain about emotional blunting when that is the entire purpose of the drug.

The ideal would be to blunt the negatives but not the positives. The effect of some of the older antidepressants can be to blunt both, across the board.

Some of the newer atypical antidepressants can address depression without making everything flat.