Thanks for the paper, it is actually quite crazy to think about when SSRI are basically the standard to treat depression.

I recently read a book about "The brain energy theory of mental illnesses"[1] which encapsulates depression and found it pretty compelling.

It seems to be a relatively new and active area of research[2], so there is hope!

[1]: https://books.google.fr/books/about/Brain_Energy.html?id=GIx... [2]: https://pubmed.ncbi.nlm.nih.gov/38183680/