I just remembered that there is also https://github.com/sunfishcode/eyra (but I think it might be a dead project) which is close to that, it had slipped my mind.
All of these are going to mean you can't link any (non-freestanding) C code, load any dylibs, etc. So you will be fairly limited in what sort of applications you can write. Forget most GUI frameworks, even native ones. You won't be able to load GL or Vulkan drivers for example. You are basically stuck with command line or servers.
I would hazard the guess that that’s perfectly fine. Desirable even. People who run scratch or alpine images and link against musl aren’t usually looking to write desktop applications or video games.