I am still impressed by QubesOS track and I use it for my dedicated 'financials' laptop.
IMHO the thing that is holding back QubesOS is the lack of hardware acceleration for graphics - maybe now when dual monitor setups are getting popular this could be a workaround for the security considerations?
Problem is not that nobody wants to do it, it is that GPU stack is exactly the kind of enormous driver surface Qubes exists to keep away from dom0. Second monitor does not really change that, somebody still has to trust the driver.
I dropped QubesOS once exactly for that reason in the past but now I’m running it again on a separate computer.
Even with all its drawbacks, there is something really nice about being able to run different applications over Tor, VPN or plain internet simultaneously, the ability to isolate non-safe binaries and being able to backup your VMs easily.
I wish a similar distro would be made based on KVM so that the standard kernel could be used. It would be great for compatibility.