I have extensively used AHK for workarounds with annoying software. Generally, it's probably the worst class in terms of a workaround if you had something specific in mind with a bit of effort you could solve this now with AI tooling to write your something that does that specific behaivour anyways.

The only valid holdup for Linux at this point is kernel anticheats and some larger commercial software that is deeply engrained in the windows ecosystem eg most desktop offline CAD software. But once again AI is going to help you get that running under wine. I am already working on a series of wine patches and a custom runner to allow me to run ProE/Creo under wine without issues.