Software
Richard Stallman: GCC and Emacs - both massive pro?ects and still going strong.
Linus Torvalds: Linux OS kernel
Science
Geoffrey Hinton: scaling neural networks
Books
Donald E. Knuth: Structure and Interpretation of Computer Programs (vol 4c of 12)
Buildings
misc. architects and builders: (most) cathedrals (Cologne, Barcelona, ...)
Knuth didn't write SICP, it's by Abelson, Sussman, and Sussman.