alt Hacker News> Neo6502 [...] consist of real W65C02S processor and RP2040 which emulates RAM memory, video, keyboard, SPI, I2C, UART, GPIOs, Sound
(via https://github.com/OLIMEX/Neo6502)
6502 is fun but coupling it to a RP2040 takes most of that fun away again, imho. Why not have the RP2040 emulate the 6502 too?
I think it works if you treat it as a black box - the RP2040 and 2350 are synchronous and can basically play the role of an FPGA here.
Although I could see a version of this with two RP2350's.