Running OpenBSD as a daily driver but with no DE.
It has a working X11 with DRM from linux as base so everything graphical will work mostly fine. The issue is more around the OS and some subsystems. OpenBSD is still using the Giant Lock model, so SMP can be an issue. Linux has more independent subsystems so heavy processing is unlikely to impact usb audio (which is an issue I have with my oldish laptop). Another issue is the input subsystem (wscons framework) which is not as sophisticated as Linux Input subsystem. In general, linux subsystems are more sophisticated/complex than their OpenBSD counterpart, but the latter work well enough.
There are some linuxisms in some applications (the recent moves to wayland/systemd,...) but they're mostly easy to port.