It should be a critical part of the evaluation. If you set the bar higher than “safer on average” then you’re going to delay the switch, and every month of delay will cost more lives. “Safer on average” is exactly when you should start using the new thing, even if it’s uncomfortable and even if it’s a low bar.
No it shouldn’t. Low risk behaviors should equal low risk outcomes. If it’s safer on average yet causes low risk behaviors to suddenly become unpredictably dangerous, folks will very reasonably push back