IMO it is literally not possible for a medium+ jQuery app to fit in a brain or be maintained easily (especially without TypeScript). That's why React et al were invented. It is smaller, faster, no build step for sure, but I would never reach for jQuery for any possibly ambitious app.

If you are using mostly agents and don't actually need to have it in your brain, then I'd probably go with strict TypeScript at the very least for verifiability purposes