It's my primary role. I started using jsxstyle a dozen years ago alongside React and really liked the ability to style my components in situ without breaking browser architecture assumptions.
I recently had to help out on a vibe coded project that inherited Tailwind (I think from Figma). It was a short assignment so I didn't dig that deep, but I don't understand the value prop of Tailwind. There was no obvious improvement over what I've been used to; in fact, it seemed a lot messier.
A lot of the time the choice comes down to abundance of resources and community support. So if we're comparing tools (e.g. jsxstyle vs tailwind) maybe Tailwind could actually win on those parameters (no actual idea, just guessing based on the number of stars jsxstyle has on Github), but if we're comparing vanilla to [any tool] then vanilla usually takes the cake.