This is awesome. I always think about this. As humans, we are very limited in what we can perceive and experience. A higher form of entity could have a completely different way of viewing nature and the world.
Just a thought experiment for you guys: imagine a bacteria that survives inside humans. It doesn't even know what a human is. For the bacteria, its entire world is simply the environment in which it lives. It doesn't know that we are living beings actively trying to maintain ourselves and survive.
Now, suppose a harmful bacteria enters our body, makes us sick, and we take medicine that kills all of them. From the bacteria's perspective, it could look like a natural disaster or some unexplained event in which they all suddenly get wiped out. They have no idea that a living being called a human actively tried to eliminate them using something called medicine, which was engineered specifically to kill them.
Similarly, what if our world, or nature itself, is part of some higher-level entity that we simply exist within? What if the reason for our deaths, natural calamities, and other events is something completely beyond our perception? Whatever we do, we may never be able to understand what is actually happening at that level, just as bacteria may never be able to understand that humans exist.
One thing that could potentially support this idea is self-regulation. We see self-regulating systems throughout nature, and these patterns seem to repeat at different scales. We ourselves are self-regulating organisms, and nature also has countless cycles and mechanisms that regulate themselves.
Maybe these patterns continue at scales we cannot perceive. We can observe certain things at the scale of humans, but we still don't fully understand what happens at the nano scale or on the scale of the universe. Perhaps there are higher levels of organization and self-regulation that we simply don't have the ability to perceive yet.
Of course, this is what the end of Men in Black shows.
https://www.youtube.com/watch?v=OKnpPCQyUec
But let me tell you another possibility. What if there is no nature, but just our perception of it.
Yea, tree falling in the forest and all that...stated more explicitly..
Cogito ergo sum is still the only "barrier" for self-awareness, aka real knowledge.