I currently have R410a heat pumps with minisplits, when they're off warranty sometime in the future I might consider putting propane in them. The main question would be whether the oil used with R410a is compatible with propane as a refrigerant.

This is probably a little bit "dangerous" in the sense that I'll have high pressure propane in the line sets and minisplits inside the house, but it's a very small volume of propane and not really any more dangerous from a fire perspective than my propane fired condensing gas boiler.

[edit] a little internet sleuthing indicates that hydrocarbon refrigerants "might be" compatible with basically any oil, so I can probably just continue using whatever oil is in it.