There are many points.

>Building things we don’t understand is a sure path to facing consequences we can’t predict.

We don't understand all of physics yet we were able to do plenty. Even before Newtonian physics we were still able to build things that last. The idea that humans have to understand everything and abstracting things will lead to ruin is not supported.

Part of math is building abstractions so that you can be able to use other people's work without fully understanding it. No one person has a full understanding of mathematics.