Nonwithstanding the human fascination with simulation and simulacra, Airplanes and Air Travel represent a fascinating cultural touchpoint with much insight and depth to plumb depending on what aspects you simulate.
For example, think of a history class charting flight from the Wright Brothers, through the Golden Age of Aviation, right to the present day. Even showing the drastic differences pre and post 9/11 by reference to the processes and experiences of commercial airline travel would represent a worthy pedagogical endeavour. We do a lot more to achieve a lot less in terms of making 'history come alive' currently.
A game where you're narcoleptic and keep falling asleep at random unannounced times. While taking a flight from A to B, you wake up at different times entirely, on the same (or an equivalent) flight, seeing whatever was going on back then. Sometimes it's a flight with the Wright Brothers, sometimes you're flying during WWII, and sometimes you might just be on the plane heading towards the twin towers (right as you wake up back on your own original flight). Maybe even some mini-games where you might have the chance to foil a hijacking in progress, or maybe you need to be "the doctor on the plane", or maybe you wake up as the guy that's carrying the crying baby. You never know when, where, or who you'll wake up as.