alt Hacker News> 1. I have had them subtly mess with websites I am working on and I probably wasted multiple hours troubleshooting an issue that wasn't an issue
If your website is going to be used by people with an adblocker, discovering that an adblocker unintentionally breaks your website is a feature of using one, not a bug.
That is true, but does not help a person who is not building a given website.
I have had financial websites impacted by adblockers, which is why I stopped using them. (I do not work on all of the teams building the financial websites I use.)